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Since naïve cells entering the immune response at a later time point express higher CD127 levels, we investigated whether blocking IL-7Rα during the contraction phase would affect the outcome of memory T cell development.
This classification system may be helpful to further study clinical determinants, i.e. psycho-physiological outcome of memory and learning performance, which is also differentially compromised in TLE patients undergoing tailored neurosurgical resections.
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Main outcome measure Tests of memory, reasoning, vocabulary, and phonemic and semantic fluency, assessed three times over 10 years.
The main effects of NET as compared to TAU and the waiting list condition on the secondary outcomes of trauma memory quality and trauma-related cognitions will be similarly analysed employing analyses of covariance.
Brain structural correlates of memory outcome were investigated with bivariate and partial correlations, as appropriate.
In accordance with international guidance (23), the main cognitive outcome was a test of memory, i.e., a 16-item word list from the California Verbal Learning Test (CVLT) (24).
Memory outcome independent of general intellectual functioning was investigated: (i) analyses of pre- to post-surgical memory change covaried for concurrent change in FSIQ; (ii) analysis of memory outcome covaried for FSIQ at follow-up; and (iii) analysis of IQ-derived semantic memory covaried for performance IQ (because of subtest overlap with FSIQ).
Stepwise linear regression analysis was used to explore clinical predictors of memory outcome after surgery (excluding brain volumetric predictors): including age at onset of epilepsy, duration of epilepsy, lesion type (DNT or hippocampal sclerosis), current seizure status and medicated versus medication-free.
Overall, large effects (ES >.05) were found for 50% of the memory outcomes in cognitive exercise trials compared to 37% of memory strategy outcomes.
Prediction of memory rehabilitation outcomes in traumatic brain injury by using functional magnetic resonance imaging.
Our work thus provides a phenotypic means to identify effector and memory cells, as well as a mathematical framework to investigate their genealogy and to predict the outcome of immunization regimens in terms of memory cell numbers generated.
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