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Our results indicate that outcomes of many RCTs remained too often centered on physiological criteria (oxygenation or hemodynamic stabilization for instance) or assessed mortality as sole outcome of importance for patients.
Another post-ICU outcome of importance is functional disability, in which physiologic insults from critical illness cause persistent disability in meeting the physical or social demands of the patient's life [20, 21].
Postoperative quality of life is an outcome of importance to all ages, but perhaps particularly so for those whose absolute life expectancy is limited by virtue of age.
In view of these past successes, there is little doubt that a major outcome of importance to the global effort to control NCDs will occur.
For each question/indication, the evidence profiles were given tentative GRADE quality criteria for each outcome of importance by the systematic reviewers (who did not participate in making guideline recommendations).
7 While this study is limited only to CF trials, it is clear that the problem of ORB is much larger when considering more than just the single primary review outcome of importance that was used in the ORBIT study.
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The majority of survey questions were open-ended and asked about outcome measures currently used, outcome measures' assessment criteria, sources of information, perceived barriers to finding outcome measures and outcome domains of importance.
This is apparent in multiple domains covering outcomes of importance to both clinicians and patients.
Outcomes of importance to patients, namely health related quality of life, should be used as primary outcome measures.
Results 13 randomised trials, of which five assessed outcomes of importance to patients, were included.
Each interviewee was asked whether key health and service development outcomes of importance had occurred.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com