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This was a controlled study, which consisted of baseline observation, intervention and outcome observation using the same measures.
The main outcome observation period was 1 week from recruitment and ended when IAD was cured.
Comorbidity was defined using only a single year of data and was based on data from the year immediately prior to the outcome observation period.
Transitional models condition the outcome in the current time on the previous outcome observation (e.g., afternoon FEV1 is regressed on the morning FEV1) (Diggle et al. 2002).
Individuals were excluded if any outcome observation was missing, leading to a total of 189 professionals in the multilevel regression analysis.
Further investigations with a longer detailed clinical outcome observation period (one to five years' follow-up period) would help to assess the course of healing of infected bone defects under this treatment.
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We made retrospective base-line and prospective outcome observations using the same measures, separated by the intervention.
Due to a limited number of explanatory variables allowed in the model (≈1 variable per 10 outcome observations in the poor outcome/CI-DCI group), a manual forward model building strategy was used.
Since this study focused on cohort average effect, no specific random effect was added to the model on any particular covariate, except assuming the existence of correlation between two outcome observations of the same subject.
All analyses were performed within the framework of longitudinal mixed models, The general idea behind mixed models for longitudinal data analysis is that an adjustment is made for the correlated outcome observations within individuals over time by estimating either the differences in average values of the outcome and/or the differences in relationships with time-dependent covariates.
Data will be independently extracted by two authors, and will include the names of article authors, year of publication, country, sample size, randomisation method, blinding, participants, intervention, duration, outcomes, observation points, results, follow-up and adverse effects.
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