Secondary outcome measures comprise informed choice and the achievement of patients' treatment goals.
Effect sizes for primary outcome measures were informed by the literature and agreed by study site clinicians.
Collect data on the variability of outcome measures to inform a sample size calculation for a larger trial.
Physiotherapists use a wide range of outcome measures to inform and evaluate their clinical practice, but selection of the most appropriate measure is challenging.
The UK Medical Research Council MRCC) sought to examine alternatives to the health-related QALY to address the problem of using multiple outcome measures to inform resource allocation within and between sectors.
Owing to increasing pressure on rheumatologists to use outcome measures to inform treatment decisions, the work by Lee and colleagues highlights the need for comprehensive RA management strategies to understand and address the human factors that influence outcomes measures.
This observational study explored the feasibility of recruiting and retaining participants, and the acceptability of outcome measures, to inform decisions about the feasibility of a randomised controlled trial (RCT).
Trial feasibility as a phase II trial we will obtain data on patient eligibility, recruitment and attrition rates, GP recruitment and attrition rates, and response rates to outcome measures to inform decisions and planning for a larger phase III trial.
As a phase II trial we will also obtain data on patient recruitment and attrition, and response rates to outcome measures, to inform decisions about a future phase III trial.
Specifically, Define the distribution (eg, log-normal, Poisson, etc for, eg, length of hospital stay) and estimate the variability for the potential primary outcome measures to inform sample size planning for a subsequent definitive trial.
