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This data indicates that the effects of the MHC disparity between donor and recipient primarily influence outcome in the initial two weeks following transplant.
The most prominent outcome in the initial phase of inflammation is the enhanced production of cytokines, such as TNF-α and IL-1, and chemokines, such as monocyte chemoattractant protein-1 (MCP-1) [11], [11], which further induce expression of a number of inflammatory cytokines [4].
Whether the rates of poor neurological outcome in the initial study would have improved over time cannot be assessed.
Of those, 6 loci were associated with outcome in the initial cohort (n = 84, log rank test, p < 0.05).
The sum and ratio scores were considered in the analysis only when the individual biomarkers had a significant association with the outcome in the initial analysis.
Patients with a good outcome in the initial 1- to 7-year follow-up continued to do well in this long-term follow-up.
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Effect of multiple physiotherapy sessions on functional outcomes in the initial postoperative period after primary total hip replacement: a randomized controlled trial.
Patients in polyamine intake quartiles 1, 2 and 3 reflected similar clinical outcomes in the initial regression models; therefore, these three quartiles were collapsed into one group.
Table 5 shows the results of multivariate logistic analyses including 11 variables to determine the factors associated with the short-term and long-term outcomes in the initial nonshockable rhythm cohort.
16 Analysis of intermediate outcomes in the initial 110 patients undergoing such surgery at our centre showed freedom from death or transplantation at 15 years of follow-up was 80%, with freedom from recurrent tachycardia of 85%.
The ratios of both short-term and long-term outcomes in the initial shockable rhythm cohort were significantly higher than those in the initial nonshockable rhythm cohort (26.7% vs. 4.7% for prehospital ROSC, 24.7% vs. 2.4% for 1-month survival and 16.3% vs. 0.6% for one-month CPC score of 1 or 2; all P < 0.001).
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