The HF-ACTION investigators devised a system to address assignment of authorship on trial publications and tested the outcomes in the course of conducting the large, multicenter, National Heart , Lung and Blood Institute funded trial (n = 2,331; 82 clinical sites; 3 countries).
Risk of bias can affect the cumulative evidence of a review of literature [33], such as selective reporting within studies, whereby researchers may under-report variables that were found to have less statistical impact on longevity outcomes in the course of reporting results that support the direction of their findings.
In the present study we hypothesize that daily monitoring of plasma CRP can recognize patients with bad outcome and patients with good outcome early in the course of antibiotic treatment.
The association of insight and non-medical explanatory models to long-term outcome later in the course of illness suggests that explanatory models are coping mechanisms rather than being causally related to outcome.
It is not the purpose of this commentary to discuss the ideal timing of CRRT during ECMO, because many questions remain to be debated, but this study confirms that AKI is a major outcome determinant in the course of ECMO.
In the present study, using the Roche Lightcycler PCR technology, presentation of results takes about 3 hours, making the test a potentially realistic and useful one in the clinical setting (when predicting outcome early in the course of a disease process).
This finding may be similar to Beng-Choon et al [ 9] and it means that duration of untreated initial psychosis is not a prognostic factor for outcome early in the course of schizophrenia, however this point still in need for further analysis and research.
While it remains uncertain whether early IT is associated with a reduction in cardiovascular endpoints, we find no evidence that such treatment adversely affects patient-reported outcomes early in the course of the disease.
The higher risk for severe outcomes earlier in the course of the Jeddah outbreak probably was due to the increase in contact tracing as the outbreak progressed in Jeddah, leading to detection of a greater spectrum of clinical MERS-CoV disease later in the outbreak.
