This was a surprising outcome, as expression of STARD3 was clearly sterol-dependent in human THP-1 macrophages (Borthwick et al., 2009) and repressed by genetic obesity in both male and female fa/fa rats (Soffientini et al., 2014).
Interestingly, a subset of GBM with better outcome shows expression alterations in components of NOTCH pathway [30].
Although in the BC we analyzed, β4 does not directly influence the patient outcome, its expression may influence a different regulation of ErbB-3 and consequently, as suggested by our analyses, PI3K activation through its heterodimerization with ErbB-2.
To couple "androgen-responsive" and "acquired resistance" genes with outcome, gene expression data from 131 primary prostate cancers were analyzed (Taylor et al, 2010).
From the above differences the only one related with final outcome was expression of HLA-DR on monocytes of patients with acute pyelonephritis.
Repression of numerous genes involved in haematopoietic differentiation, including CEBPA and SPI1 (PU.1), likely plays an important role in the functional outcome upon expression of AML1-ETO.
Second, several factors that are associated with active CD8+ cytolytic responses are also linked to favorable outcomes, including expression of IFN-γ [14], [15], the IFN-γ receptor [16] and IL-18 [17].
No significant association was seen between outcomes or expression of angiogenesis-related proteins and hypertension.
As activation of P53 pathway can lead to many significant outcomes, the expression of P53 needs to be strictly regulated.
First, it describes the only direct comparison of the transcriptional outcomes of expression of CAG and CUG expanded repeat RNAs.
