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DC appear to be able to edit exosome processing, with a final outcome directed toward tolerance rather than immune stimulation, depending perhaps on the route of MV administration or on their antigenic mosaic.
Our data support a key protective role for IFN-γ signalling in limiting cartilage deterioration in early inflammatory arthritis; an outcome directed by IFN-γ's capacity to modulate the synovial expression of IL-1β and attenuate IL-1β-induced MMP production by FLS.
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These effects can even be in opposite directions for the various PFAAs, and because the concentration effect curve is biphasic, different levels of exposure can be expected to produce disparate outcomes directed toward a given neurotransmitter phenotype.
A focus on outcomes directs attention toward the main goals of the new environment, and users are the central focus of the planning and design; thus, design decisions should be based on the results of these outcomes.
In light of the weak association between many processes of care and outcome, direct outcome measures, such as PSI and related measures of adverse events, may have an important role in future efforts to improve health care quality.
The Event Rate was the proportion of participants with a partial satisfactory response, not warranting further treatment or complete resolution of symptoms and signs for the outcome direct treatment response.
A fascinating outcome of directed evolution is that new insights into mechanistic enzymology can be gained.
Having wings certainly enables (some) birds to fly, but it is unlikely that selection forces acting on an avian ancestor anticipated this outcome and directed evolution accordingly.
The secondary outcome is directing use of services towards quality of life in the last year of life.
Table 2 Multivariate regression models showing association between first grade teacher's contact with preschool centers and child outcomes Direct effects Initial social adjustment Initial academic adjustment General motivation Communication skills Academic skills Externalizing behaviors Social skills Coef.
Although neighborhood characteristics have important relationships with health outcomes, direct observation involves imperfect measurement.
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