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Clinical outcome dates in CKD patients are lacking.
Case-patients require additional input of their illness-onset dates, types of outcome, outcome dates, and whether or not they are the index patient in the outbreak.
For those patients with discordant outcome dates, the mean difference was 14 days with a median of 7 days (IQR: 2-17).
According to Maldonado and Greenland [ 16], this definition of a counterfactual causal effect on a binary outcome dates back to the 18th century when the Scottish philosopher David Hume wrote: "We may define a cause to be an object followed by another... where, if the first object had not been, the second never had existed".
Although some alternative analytical methods are available to allow for interval censored data these tend to make stronger assumptions than Cox regression about the distribution of the hazard rate, and often group all outcome dates into fixed intervals, hence potentially losing precision.
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This includes demographic information, initial body weight, patient category based on previous treatment, treatment starting date, bacteriology and outcome (dated).
We defined outcome date as the date when the young fledged or were found dead (June 1 June 29).
The date of death or admission served as the outcome date in all analyses.
All researchers and clinical staff involved with generating outcome date were blind to participant allocation.
Only the POCT outcome, date of testing, patient number and the clinic name were recorded on the study form.
For each participant we calculated time at risk until date of each outcome, date of emigration, or the end of the study period (31 December 2010), whichever occurred first.
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