Other goals are: international standardization of outcomes; consensus on composite endpoints, biomarkers, surrogates and measures of disability; greater efficiency through randomized factorial designs and cluster or cross-over cluster RCTs; and equipping parents as partners in all aspects of the conduct of RCTs and in implementing their results.
Regional citrate anticoagulation is increasingly used, and is currently recommended by the Kidney Disease: Improving Global Outcomes consensus group as the preferred anticoagulant for CRRT both in patients with and without increased bleeding risk (level of evidence 2B and 2C, indicating a suggestion based on low quality of evidence) (data not yet published; M Schetz, personal communication).
The static process of survey methodology makes it difficult for participants to respond to each recommendation from other participants, which may effect consensus outcomes.
Following his win Hamilton told the BBC: "We've achieved an outcome by consensus.
A common practice is to combine the predictions of several models into an overall outcome using consensus based reasoning.
The respective outcome and consensus are reported herein.
The data in our study were not suited to assess the performance of individual radiologist radiographer double-reading, as the radiographers had reported the outcome after consensus reading.
Molecular subtyping may provide additional information on patient outcome, but consensus has yet to be reached regarding IHC or ISH markers that could be used as surrogates for gene expression analyses [ 17].
In cases when no definitive adjudication could be made on the basis of the above criteria, an adjudication committee consisting of clinicians with expertise in acute paediatric care assigned outcome by consensus, using all available information.
For the purpose of this study, two experienced clinicians (GB and MM, blinded to the MRI results and further clinical outcome), in consensus, rated the combination of the DRE and endoscopy findings and assigned a confidence level score for the overall clinical assessment (Table 1).
