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"We need to have protocols ready to go, we need to have a task force of research staff in each region on standby to be deployed into the next outbreak trials," she said.
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The study faced challenges in getting enough patients enrolled in the trial before the outbreak ended, and there is concern that trial participants in later stages of infection provided a poor baseline for the drug's efficacy.
During the feeding trial an outbreak of amoebic gill disease occurred and the fish were effectively treated by freshwater bathing.
These results are coherent with the pathology as described from clinical outbreaks and previous challenge trials with CMS [ 4, 7, 8].
"I don't think this can be seen as the primary answer to this particular outbreak," he said, but the trials under way could help in the future.
There is little doubt that launching clinical trials in an outbreak is fraught with difficulty, partly because a new or rare strain of disease can infect so many and overwhelm health services and partly because there are many bureaucratic hurdles.
"If just one of those promising vaccines had been through (early stage) phase I trials before the outbreak started, public health workers could have begun vaccinating people at the start...potentially saving thousands of lives".
Measles was present in Guinea-Bissau and shortly after the trial started an outbreak occurred in the study area and provided a unique situation for testing the efficacy of vaccination before 9 months of age.
This is primarily due to the failure to undertake trials in the last outbreak".
A vaccine against Ebola has been shown to be 100% successful in trials conducted during the outbreak in Guinea and is likely to bring the west African epidemic to an end, experts say.
13 15 Moreover, a prospective controlled clinical trial conducted during the outbreak in the Netherlands showed no benefits of screening for antibodies against C. burnetii during pregnancy.
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CEO of Professional Science Editing for Scientists @ prosciediting.com