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During the course of the outbreak, testing for alternative causes that could fully explain patient illness was ordered at the discretion of local clinicians, and SARS was often excluded on the basis of local interpretations of test results.
This process of notifying local/state health departments of disease, subsequently investigating the outbreak, testing specimens, and voluntarily reporting to the national surveillance system can vary widely in duration (days to months), which makes timely and uniform monitoring on a national level challenging (9, 10 ).
Many aspects of our laboratory pandemic planning worked well in practice; outbreak testing facilities and equipment platforms provided the required test capacity (as many as 1,400 extra PCRs in 1 day).
Although PHL had chain-of-custody experience through its Toxicology and Environmental Laboratories and outbreak testing during the West Nile outbreak, nothing could have prepared the laboratory for the events of October 2001.
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The lettuce linked to the April outbreak tested negative for the more famous form of E. coli, but no one checked it for the other strains, according to the Ohio company that processed it, Freshway Foods.
Some animals from other species that were in the affected pet distribution facilities during the outbreak tested positive for MPXV.
Long-term maintenance of F. tularensis has not been shown to occur in deer flies, and it is therefore not surprising that the deer flies we collected 3 weeks after the outbreak tested negative for this organism.
Operationally, the pandemic (H1N1) 2009 outbreak tested our laboratory preparedness in ways that no exercise could; yet some of the potential pressures were limited by the relatively low clinical severity of the virus.
Most of the 26 M. abscessus subsp. massiliense strains not related to outbreaks tested did not harbor this 2-SNP rpoB signature.
Although the DENV cases were few, 8 of 48 (≈17%) DENV-2 positive patients from towns affected by the 2 outbreaks tested positive for CHIKV (Table).
The results from field outbreak tests and cell culture analysis along with measurements of specific antibodies against AIV demonstrate that the mortality associated with AI infection can be reduced by using a receptor blocker against AIV.
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