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Twenty-seven isolates from Africa and the Middle East showed the outbreak resistance pattern, but they were susceptible to nalidixic acid and fully susceptible to ciprofloxacin.
PCR and whole-genome sequencing analysis by use of ResFinder (http://www.genomicepidemiology.org/) identified the original outbreak resistance determinants and additional determinants (aac(3 )-IIa, blaCMY-2, blaCTX-M-2, bla TEM-1, dfrA15, mphA, sul1, and tetA) (7 ).
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In 46 he crushed their army at Thapsus and returned to Rome, only to leave in November for Farther Spain to deal with a fresh outbreak of resistance, which he crushed on March 17, 45 bce, at Munda.
Unlike the outbreak of resistance, what happened next was predictable.
Eleven meningococcal isolates from the recurrent outbreak showed resistance to ciprofloxacin as well as nalidixic acid (Table).
During the outbreak, carbapenem resistance was found in 53% of A. baumannii isolates and 24% of P. aeruginosa isolates.
Viruses isolated from a sample of patients with confirmed cases in early phases of the outbreak demonstrated resistance to amantadine and rimantadine.
Antimicrobial susceptibility testing of all MRSA isolates from the 14 infants involved in the outbreak indicated resistance to β-lactam antibiotics, gentamicin, erythromycin, clindamycin and tetracycline, but susceptibility to ciprofloxacin, linezolid, rifampicin, sulfamethoxazole-trimethoprim, teicoplanin, tobramycin and vancomycin.
For instance, one of the first outbreaks of resistance development among target organisms on GM Bt maize were reported in South Africa, partly explained by farmers' failure to comply with resistant management strategies such as refuge requirements [70].
Outbreaks of resistance occurred in multiple species-groups simultaneously for 44% of assessed antibiotics (7/16).
Twenty-four oftbresistanceesistance were detected in ICU-1 and 15 in ICU-2.
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Justyna Jupowicz-Kozak
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