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Under non-stress conditions, there exists equilibrium between the import and export of WT p53 in and out of nucleus.
In fact, JNK1 was also reported to antagonize Wnt/β-catenin signaling by expelling β-catenin out of nucleus [4] and promoting its degradation [2].
Furthermore, 14-3-3 σ is actively exported out of nucleus by CRM1, [51], a nuclear protein that is frequently over-expressed in ovarian cancer [52].
After splicing, mature mRNA has to be exported out of nucleus to be either translated or degraded in the cytoplasm.
The partially assembled SRP is exported out of nucleus in the cytoplasm and is joined by SRP54.
These KAP proteins recognize either nuclear localization sequences (NLS) or nuclear export sequences (NES) and direct transport into or out of nucleus (Pemberton et al., 1998).
Similar(49)
But in neutrinoless double beta decay, only two electrons would come out of a nucleus.
Because APC helps shuttle β-catenin out of the nucleus (Henderson 2000), this allows nuclear accumulation of β-catenin.
We have recently shown that dtorsin is involved in export of large RNPs out of nuclei on the way to the neuromuscular junction (Jokhi et al., 2013).
To test, if our system can be used to identify CM nuclei out of total nuclei from hearts, we isolated cardiac nuclei from adult H2B-mCh mice and analyzed these by flow cytometry.
After all, in cloning, if you suck out the nucleus of a cell and replace it with the nucleus of a completely different kind of creature, it will grow into an adult dictated by the new, injected nuclear DNA.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com