Our study uncovers the molecular heterogeneity of SLE and provides an explanation for the failure of clinical trials.
Taken together, our study uncovers a novel miRNA, miR-124, that is responsible for early hepatic TG accumulation, preceding the systemic metabolic disorders.
Our study uncovers a premeiotic role for an invertebrate boule homolog and offers a tractable invertebrate model system for studying the premeiotic functions of the DAZ protein family.
Our study uncovers a viral-based dual regulatory program that restricts antiviral immunity by direct interaction with and modulation of host proteins.
Collectively, our study uncovers a chromatin-bound factor that serves an accessory role in coupling damage signaling with chromatin changes in response to DNA damage.
Our study uncovers the molecular details of Eaf3-methylated H3K36 complex formation, and suggests that, in the cell, Eaf3 can only function within a framework of combinatorial interactions.
First, our study uncovers unique SC- and EMT-enriched gene-expression profile in unperturbed basal cells that support the long-held hypothesis that the human prostate basal cell layer harbours primitive SCs.
Collectively, our study uncovers a novel signaling role of Dsg3 that acts as a cell surface activator of AP-1 and the PKC/Ezrin pathway that promotes cancer cell migration and invasion.
Our study uncovers the evolutionary strategies by which vaccine strains become pathogenic and provides a powerful framework for rational design of safer vaccine strains and for forecasting virulence of viruses.
