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Although the techniques we applied in our study compromised our ability to detect missense mutations in regions of the BRCA1/2 genes screened only by PTT, at present the majority of reported missense alterations are difficult to interpret with respect to potential clinical significance, as the effect of the amino acid substitution on protein function is not yet well understood.
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Systematic review procedures address study credibility by assessing internal validity or "risk of bias" — the assessment of whether the design and conduct of a study compromised the credibility of the link between exposure/intervention and outcome.
First, some critics argue that features of the study compromised the fiduciary duties the physician owes to her patient (Annas and Annas 2013; Carome and Wolfe 2013; Sharav 2013).
A very low prevalence of persistent CMD in the current study compromised the power to detect any meaningful effect.
Furthermore, the limited sample in this study compromised reliable analyses of differences between individual wards or type of staff due to questionable power.
For the same reason as well as illegitimacy of sexual relation and having prior to marriage children, the population of present study compromised married women with PCOS.
Our study was compromised by the lack of detailed qualitative data to fully explore issues related to why users sometimes ignored DDSS advice, or specific cases in which users found the DDSS useful.
First, the single-center nature of our study might compromise the generalization of the results.
Thus, more studies are needed to improve the conclusions on this subject for ESRD, since the cross-sectional characteristics of this study compromise the data inference.
Funnel plots and the Egger's regression asymmetry test (data not shown) did not reveal evidence for publication bias, although small number of studies compromised this analysis.
Our study may also be compromised by completeness of surgery, radiation, and, in particular, chemotherapy data.
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