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We use country fixed effects in all our pooled regressions to account for country idiosyncratic characteristics.
4 of these 5 indels matched indels called in our pooled data.
We used the trim and fill method to recalculate our pooled risk estimate.
Rubin's rules were applied to the imputation-specific performance measures in our "pooled performance" approach.
Our pooled data were therefore for 3,012 subjects ranging in age from 55 to 102 years.
A key aspect in our mutation detection pipeline was to take into consideration the dilution effect of each variant due to our pooled sequencing approach.
With our pooled 20percenttimeme, we slowly turned the organization on its axis and made developer testing a common part of the development practice.
For both BCM (Supplementary Fig. 3) and BCS (Supplementary Fig. 4), we found that most single animals were consistent with our pooled results, showing a peak.
In this study, we conducted sensitivity analyses to explore the sources of this heterogeneity by removing one study at a time from our pooled analysis.
To estimate the reduction in costs derived from the use of our methodology we compared the costs per patient of our pooled method with an individual sequencing approach.
As expected, gene-deletion mutants specific to direct, base excision, and recombinational DNA repair pathways were identified as MMS-sensitive in our pooled assay, thus validating our resource.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com