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The comparison with other simulation techniques outlines the capabilities of our method to provide an accurate modelling together with a very simple circuit implementation.
> We envision one application of our method to provide a means for representing canonical disease states.
We have used our method to provide insight into the functions of transcriptional regulators in MTB.
Despite the ability of our method to provide hints about the lack of causal relationship between the circuit components, in this case, further tests are needed using different input schemes to uniquely determine the correct topology.
The generation of similar experimental datasets in higher eukaryotes will allow us to apply our method to provide further insights into the mechanisms of cooperativity between remodeling and modifications.
We note therefore that, given unavoidable uncertainties in background properties in vivo, that we do not expect our method to provide absolute quantitation of lesion thickness and depth, but rather relative measures of a lesion's thickness and depth that are robust and provide clinically useful information.
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We intend to hone our methods to provide more refined and flexible results, such as fully modelled complexes and specific ligands.
However, mapping mutations to the individual domains illustrates the value of our domain-centric method to provide the essential functional context to explain the role the mutations in cancer development.
"It's important that our planet find a method to provide green energy," he says.
We have chosen our experimental methods to provide the most optimal compromise between the ease of carrying out the measurements and for ensuring comparability with PEMFC conditions.
In this work we performed a systematic comparison of unweighted integration and our proposed weighted combination methods to provide an evaluation of the impact of network integration on gene prioritization.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com