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We completely agree that the concepts are quite different, and in our initial submission we did not intend to claim that this LRH-1-initiated pathway for ER stress resolution is a fourth branch of the UPR.
"Our initial submission was rejected, an appeal has went in, and we are working with Apple to resolve," he said.
This result is slightly better than our initial submission to the challenge.
These ion channels were not studied in our initial submission.
This was indeed unclear in our initial submission.
We apologize for not including and discussing fitting errors in our initial submission.
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See Preparing your initial submission which includes a word template and provides guidelines for each section of the manuscript.
We agree with the reviewer that aerobic metabolism is not limiting at the thermal limits (as we wrote in our very initial submission), and apologize for probably not having been sufficiently clear on this point in our last submission.
As a result, in full agreement with our interpretation in the initial submission, YidC mutants V500C and T503C in TM5 do not crosslink to the nascent chain.
In a study published after initial submission of our manuscript, Song et al. tested their tsunami generation theory by comparing simulations using initial condition (8 and 9) to tide gauge and DART data from the 2011 Tohoku event (Song et al. 2017).
Since the initial submission of our data, a very limited report described Kaiso's presence at centrosomes and midbody [43], which confirms our observations.
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