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And our initial discovery is that these compounds can effectively recognize HSO4−.
Herein, we describe our initial discovery and the SAR of the first such compounds with matched potencies at both receptors.
Our initial discovery of 8-hydroxyquinoline inhibitors of BoNT/A and separation/testing of enantiomers of one of the more active leads indicated considerable flexibility in the binding site.
Inspired by our initial discovery about a series of neuraminidase (NA) inhibitors targeting the 150-cavity, in present study, we designed, synthesized, and biologically tested a panel of novel oseltamivir derivatives with C-1 modification, targeting the 430-cavity, an additional binding site which widely and stably existed in both group-1 and group-2 NAs.
Our initial discovery of this behavior was itself serendipitous: one of us (SZ) was walking through some unusually loose sandy drifts on Cumberland Island and happened to kick up some C. d. media larvae, which promptly started wheeling.
The association of the NOD2 SNPs with CD susceptibility was found in both our initial discovery cohort from the University Hospital Munich-Grosshadern (Supplemental Table S3) and the replication cohort from the University Hospital Munich, Campus Innenstadt and from Ruhr-University Bochum (Supplemental Table S4).
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To establish if our initial discoveries - that CSE upregulates FimA production while downregulating capsule production [14] - influence biofilm formation, CSE-exposed and unexposed P. gingivalis was grown in an open flow biofilm system.
After these intensive talks, we were given 24 hours to create a fictional company, which we named 'Geneswitch', based on our initial experimental discovery.
A decade on from the initial discovery of histone lysine demethylases, our understanding of how these fascinating enzymes function in cells has progressed at an immensely rapid pace.
"The Secret Life of Pronouns" outlines in lively and accessible detail how that initial discovery led Pennebaker to appreciate the many ways in which function words reveal our interior lives.
In the first weeks of the initial discovery, the tumor doubled in size and paralyzed Jairo.
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