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Taking our fitted linear model S = αn, we can substitute n = S/α in (20) and find that <img src="http://journals.plos.org/plosone/article/asset?id=info?doi/10.1371/journal.pone.0002051.e036.PNG" class= inline-graphic"/> Substituting our found values of 〈k〉 and α for the fits to either Sws or SΔ confirms that this is a good approximation.
Even more interesting is that LR1-binding activity was also reported to be dependent on phosphorylations of LR1 [35] and our found interaction between Oct4 and Ncl is only occurring when Ncl is phosphorylated, indicating a similar mechanism for Ncl-P/Oct4 as components of a transcription factor complex in ES cells.
About 5.2 kbp of our found candidate fRNAs overlapped with already annotated rRNA, snRNA, and tRNA genes, indicating the capability of our approach in finding non-coding RNAs.
Structural RNA elements also cannot be identified using FIRE; nonetheless, some of our found short motifs may represent the most functionally important regions of RNA structural elements.
Within probably three months, I went out and purchased a whole stack more of them; wrangled some money out of our, found some money, and I got one and put them in each of the work units in my division.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com