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Our elucidation of the processes that underpin human growth is central to understanding normal as well as abnormal development.
Thus, based on our elucidation of the CAPN3 cleavage motif we find explainable disturbances in the levels of two predicted substrates in patients.
Our elucidation of the molecular defect caused by mutations in Rab7 illustrates an alternative mechanism: toxic misregulation of native function.
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Following our recent elucidation of the fact that bioactive 5-deazaflavins stabilize and activate p53 by binding directly to the HDM2 RING domain, here we have presented a comprehensive SAR analysis of 5-deazaflavin as inhibitors of p53 ubiquitination by the p53-specific ubiquitin E3 ligase HDM2.
Our recent elucidation of a community map for PKA shows clearly how the C-tail and β strands one and two function as an integrated community in the closed conformation, whereas this community is uncoupled in the apo conformation (McClendon, C. et al., manuscript in preparation).
Public health implications of our findings await elucidation of the contexts in which and mechanisms through which maternal depression may affect growth in children.
In our humble opinion, elucidation of the type of Smurfs-mediated ubiquitin modification of Ptch1is certainly informative, but is nevertheless a mechanistic detail in our investigation.
Since our focus is elucidation of genes preferentially transcribed under FeHm restriction, we primarily selected targets from the FeHm-ve genes.
Our mass spectrometric elucidation of the SLP65 interactome circumvented common disadvantages associated with conventional approaches to characterize protein complexes, for example, weak signal-to-noise ratios, loss of binding partners owing to antibody-mediated complex disruption and in vitro enrichment of false positive candidates.
A betrayal or a tasteful elucidation of our green and pleasant land?
But it is of central importance for further elucidation of our concept of personal memory.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com