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The level of recombination detected in our datasets is below the threshold level suggested by Anisimova et al., (2003), above which recombination may be mistaken for molecular adaptation.

A summary of our datasets is described in Table 1.

The number of Taste2s in our datasets is equal or close to previously reported numbers [ 30- 35].

In addition, a flow chart summarizing the procedure used for preprocessing our datasets is provided in Supplementary Figure S3.

However, a closer inspection of the sequence alignments indicates that the species in our datasets is not exactly this, but a related species.

Because each of our datasets is identical (up to permutation of gene names), these distributions should be close to identical, as is the case.

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We do not often have whole skeletons preserved in 3D, so our datasets are incomplete.

Non-photorealistic renderings of our datasets are also possible.

WA values from all publically available Repli-Seq datasets and our datasets were quantile-normalised prior to performing PCA and hierarchical clustering.

All positives in our datasets are therefore correctly labeled.

Our datasets are subgraphs of the Facebook ego network.

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