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Taken together, our data has established that Berberine chloride exerts its leishmanicidal activity both directly, by inducing an oxidative burst in parasites [10] and indirectly, via an increase in IL-12 through enhanced phosphorylation of p38 MAPK.
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Our data have established two empirical findings.
Thus, our data have established a mechanistic basis to explain the resistance to chemotherapy often observed in advanced prostate cancers.
As our data had established a strong correlation between H3K9Ac and H3K56Ac levels, we used ChIP to analyse the presence of H3K56Ac at the CDK1 and CYCLIN B1 promoter regions.
So far, our data have established that SAGA promotes the attachment of non-chromosomal DNA circles to NPCs and that this attachment is essential for the efficient retention of the circles in the mother cell.
So far, pre-clinical data has established the potential of these inhibitors in tumours that have lost PTEN and became dependent on PI3Kβ [14] 14].
Examination of the previously published preparation and structural assignment of 4a by additional NMR and X-ray crystallographic data has established that nucleophilic addition to the intermediate 2β-methanesulfonyloxymethyl-3β- 4-fluorophenyl tropane unexpectedly provided the aza-bicyclo[3.2β-methanesulfonyloxymethyl-3β- 4-fluorophenyl tropane
Prospective placebo controlled data has established the superiority of haloperidol over benzodiazepines (Breitbart et al 1996).
Epidemiological data has established that physical inactivity increases the risk of many chronic diseases including atherosclerosis [ 1- 3].
A large body of data has established a link between cholesterol homeostasis, apolipoprotein E polymorphism and APP processing (Ref. 122).
A growing body of preclinical and clinical data has established the importance of Cav-1 in the development of virulent prostate cancer.
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CEO of Professional Science Editing for Scientists @ prosciediting.com