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Nonetheless, it is plausible to assume that the calculated sensitivity of our BIS threshold would have been higher if NMB were administered continuously.
Participants were ascertained from: the NCI-DCEG Familial Cancer Registry (41/156; 26%) and various healthcare providers (99/156; 64%), primarily in response to mailed recruitment letters, or were self-referred from our BIS website 16/156 (10%) [ 39].
We did not have a useful measure of daytime sleep because our actigraphy data significantly overestimated nocturnal and diurnal sleep quantity [ 21] and our BIS recording was restricted to the nocturnal period due to patient tolerability.
Differences between our BIS SEI results and those of our other measures may be explained somewhat by residual neuromuscular weakness in patients recovering from sepsis (actigraphy), the use of hourly epochs (nurse assessment), and limitations in the patients' ability to complete the RCSQ (patient assessment) [ 21], all of which may lead to overestimates of sleep quantity and SEI.
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