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The high prevalence of overt DIC (80%) in drowning compares with 63% in our APL patients, to 33% reported for CA (22) and to 10 50% published for sepsis (23).
In contrast, no correlation between APTT and fibrinogen was seen in our APL cohort although prolonged APTT is a known risk factor associated with hemorrhagic complications in APL (24).
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Based on the results of the in vitro assays, it was expected that some of our APLs would be able to modulate EAE.
Our analysis of the inhibitory mechanisms of APLs indicates that our APLs can function as TCR antagonists; however, they can differentiate naïve CD4+ T cells to Th17 cells, but not Th2 cells or regulatory T cells.
4, 16 In our study, APL correlated with mothers' APL before 6 months and mostly disappeared after 6 months, which helps the argument for passive transplacental transfer.
For comparison, in our 142 APL patients younger than 60 years and treated with the AMLCG-type chemotherapy, the ED rate was only 8%% [ 15].
Our study, analyzing 239 APL patients, showed a significant correlation between CD56 expression with lower platelet counts and severe DIC.
Our previous studies suggested that 4-Amino-2-Trifluoromethyl-Phenyl Retinate (ATPR), a novel all-trans retinoic acid (ATRA) derivative designed and synthesized by our team, could induce differentiation of APL cells in vivo and in vitro.
However, down regulation of EZH2 by DZNep, as previously shown by Jiang et al in colorectal cancer cells, was not seen in the APL samples used in our studies.
We did not find aPL at baseline in our patients with RA.
However, in our study arsenic was administered to APL patients via intravenous infusion, and it was unlikely that MMMTAV in the saliva of APL patients was produced in the gastrointestinal tract.
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