Future research will aim to determine if any of these changes or any cofactors to the enzyme AcNOS can enhance or otherwise alter the function of this AcNOS gene and gene elements, thus contributing to the refractoriness phenotype for novel malaria control strategies.
PPIs include interactions where two proteins physically bind to one another to form a complex or otherwise modify the function of one or both proteins.
Because the accumulation of Bag6* upon USP13 depletion is significantly reduced in cells co-depleted of USP13 and gp78, we propose that USP13 is required to antagonize a promiscuous activity of gp78 towards Ubl4A, which would otherwise impair the function of the Bag6 complex by altering its interaction pattern and/or increasing its cleavage by a cellular protease.
Among the four genes described in this study, trc, fry, and msn are essential for viability, further validating the utility of mosaic screens for identifying the function of otherwise lethal genes during oogenesis.
Although off-target effects are more and more discussed, the inhibition or down-regulation of proteins by RNA interference has proven to be an excellent tool to obtain unbiased information about the function of otherwise poorly characterized proteins in many instances, also including studies on CT antigens [ 21, 22, 29].
Otherwise, the residual function of the cochlea will be damaged.
Otherwise, the putative function of the closest Arabidopsis homologous gene was indicated to facilitate comparison (Additional file 2 Table S2).
This nonsense mutation lead to premature termination of transcription at the long grain variety, indicating that long grain resulted from the loss of the function of the protein otherwise producing short grains (Fan et al. 2006).
One of the important characteristics of Human Immunodeficiency Virus (HIV) is its ability to interact with many cell types and its capacity to alter the function of chemokines that otherwise work in harmony with the immune system.
The function of the tethered protein whether that be stability, translation, localization, or transport, or otherwise is then assessed.
