Sentence examples for otherwise efficacious from inspiring English sources

The M31I 1b:2b replicon was similarly sensitive to an active-site nucleoside inhibitor of NS5B as genotype 1b replicons, but was insensitive to two non-nucleoside inhibitors which were otherwise efficacious against the genotype 1b replicons.

This would create a window of opportunity to intervene timely and avoid incompliance and discontinuation of an otherwise efficacious treatment.

It is generally accepted that biofilms, comprising conglomerations of cells attached to a solid support and embedded in a matrix of extracellular polymers, represent a major problem in clinical practice, due to their formation on implanted medical devices [ 3] and their intrinsic enhanced resistance to antibiotics that are otherwise efficacious against the bacterium's planktonic life forms [ 4].

Systemic off-target toxicities, including neurotoxicity, are prevalent side effects in cancer patients treated with a number of otherwise highly efficacious anticancer drugs.

Note, it does not follow from our assumption of unbiased copying that observers would be equally likely to adopt otherwise equivalent efficacious and ineffective practices, since demonstrators would be more likely to abandon the latter, as discussed below.

A therapeutically even more important observation is that Raf inhibitory drugs can activate the ERK pathway, and in clinical trials may be responsible for some adverse side effects of otherwise highly efficacious Raf inhibitors [ 60, 61].

Where there is an associated research program, it is either focused on evaluation [ 42, 43] or commissioned to explore the 'bottlenecks' that hinder what should otherwise be an efficacious intervention [ 44].

We conclude that the requirements for animal testing found in the Nuremberg Code were based on scientifically outdated principles, compromised by people with a vested interest in animal experimentation, serve no useful function, increase the cost of drug development, and prevent otherwise safe and efficacious drugs and therapies from being implemented.

The potential clinical impacts of missing this information are unknown, but would include drug interactions, adverse effects or other side-effects otherwise attributed to proven efficacious medications.

Off these strategies, data fragmentation, data allocation and replication, and sites clustering are the most immensely-used efficacious techniques that otherwise DDBS design and rendering would be prohibitively expensive.

This feature allows the members -- the consumers -- to purchase essential and efficacious medical therapies whose costs might otherwise be prohibitive.