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This has been realized with the advent of synthetic antibody libraries that possess diversity outside the scope of natural immune repertoires and are thus capable of yielding specificities not otherwise attainable.
Moreover, synthetic associations between endogenous regulatory elements and tissue-specific silencers may facilitate useful expression patterns not otherwise attainable by standard promoter/enhancer characterizations.
It is therefore possible that SYMRK overexpression imposes a deregulated state on CCaMK that is otherwise attainable artificially through the deletion of its regulatory domain.
Where participants were optimistic about improvements in these aspects of their life, and if they saw substance use as a potential barrier to something that was otherwise attainable and strongly desired, then they spoke of being prepared to give up substances.
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Because she and Sean started their own careers in the corporate world, and because they made a new, drum-centered life for themselves, as adults and against considerable odds, she feels that they are uniquely qualified to transmit and embody the corporate credo that any target, sales or otherwise, is attainable through hard work and what she calls a "can-do attitude".
This flexibility provides an opportunity to increase activity, prevent the development of resistance, or introduce unique modes of action that are otherwise not attainable via standard monoclonal antibody formats targeting a single antigen.
This allows access to NCs and HNCs otherwise not attainable.
Complete surgical resection of hepatic metastases represents the only curative option: cure is otherwise not attainable.
Optical mapping provides linkage information that is otherwise not attainable from short reads, and can predict large SVs more easily than the read-mapping method.
Teaching of essential surgical procedures will therefore be integrated into the MUHAS curriculum in the near future so that students may learn skills that are otherwise not attainable.
By eliminating expression in non-targeted tissues, the silencer element serves to produce the desired expression pattern; e.g., a cell-specific expression domain that might not otherwise be attainable.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com