For anti-metastatic drug discovery, more works are needed, such as setting up unbiased gene expression signature from publications by other lab (Landemaine et al., 2008; Harrell et al., 2012), or using this approach to other types of organ specific cancer metastasis.
A similar limitation applies to coping with individual-specific epigenetic drifts associated with aging [ 42– 44] and recovering from other types of individual-specific lesions (e.g. microinfarcts in various tissues [ 45, 46]).
Our findings help to elucidate the role of A-to-I RNA editing in the regulation of tissue-specific development and function, and the approach utilized here can be broadened to study other types of tissue-specific substitution editing.
This strategy may be applied to study other types of tissue-specific substitution editing in different species.
Other types of organ-specific scanning were optional but recommended in cases of symptoms or biochemical abnormalities.
As VIP is painful in many but present only in some people with LBP, the subpopulation with painful VIP would become submerged in the larger group of people with (other types of) non-specific LBP.
ITS amplification in this particular MCR chromosome is most likely correlated with other types of species-specific repetitive DNA, rolling circle replication, or mechanisms that allow tandem amplification of the canonical telomere sequence within satellite DNA, rather than be derived from gross chromosome rearrangements, such as inversions [ 60].
The excess in all-cause mortality is not due to only suicide (12) and seems in most, but not all, studies (13)—to apply to cardiovascular mortality (14, 15) and mortality from external causes (16, 17) more than to other types of cause-specific mortality.
The treatment principles for LBP and for other types of non-specific muscle pain, have changed over the last 15 to 20 years, from traditional treatments like bed rest and inactivity to more active treatment strategies ("The back pain revolution")[ 6].
