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However, the number of experimental samples possible in these systems is limited: using a large cohort is cost-prohibitive and ethically questionable, and animal welfare considerations limit the volume and frequency of blood or other tissue sampling.
The microdialysis method used in the present study has been applied to a variety of human tissues including brain, adipose tissue and peritendinous tissue [ 38- 40] and is generally considered a minimally invasive procedure compared to other tissue sampling techniques.
In contrast however, few CPI-4 transcripts were detected in the roots and branches of the second Robusta sample (data not shown), suggesting some possible maturity or other tissue sampling related differences could be involved.
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This would explain the much higher CO levels compared to the other tissues sampled.
Other tissue samples did not demonstrate any difference in drug concentration.
These biomarkers, whether biomarkers for cancer or other diseases, may be of varying molecular types, such as; proteins, DNA, RNA, and metabolites, are found in e.g. blood, urine or other tissue samples.
A limitation of our study was the lack of a gold standard for comparison like real-time PCR from vitreous or other tissue samples from the eye to confirm our diagnosis, nor was organism isolation from sputum samples used, which is the standard method of diagnosis for pulmonary TB.
Upon her death, the healthy ovary and other tissue samples were immediately taken to a lab in Italy, where scientists plan to use them to study northern white rhino reproduction. .
Infectious virus was not detected in any other tissue samples for any serotype.
Significance analysis identified genes differentially expressed in islet tumors compared to all other tissue samples in the dataset (Data S5).
ThTP was present in nearly all brain and muscle samples and in ∼60% of other tissue samples, in particular fetal tissue and cultured cells.
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