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In the signaling motif-C, mutations P565G and P560A/P565A showed drastically reduced drug-resistance activity, while activities of other mutations at the flanking proline residues reduced slightly.
Occurence of deletions and other mutations at different rates in different portions of the cluster results in a complex process of aflatoxin biosynthesis loss.
Computational modeling of the PyrR 5'-phosphoribosyl-α-1'-pyrophosphate (PyrR 5'-phosphoribosyl-α-1'-pyrophosphateveral other mutations at the PyrR 5'-phosphoribosyl-α-1'-pyrophosphateir PyrR 5'-phosphoribosyl-α-1'-pyrophosphate
Thus, the queried mutation was accurately discriminated from other mutations at the same site.
37– 41 MEK and ERK phosphorylation was also inhibited in melanoma cell lines expressing other mutations at the V600 position, including BRAFV600D, BRAFV600R, and BRAFV600K.
Given the dramatic effect upon gating observed in the Tyr34Phe hMnSOD mutant, a series of other mutations at position 34 in the human MnSOD were produced.
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Among others, mutations at positions 77, 88 and 30 contributed with a negative scoring coefficient to the first component, meaning that the presence of such mutation would decrease the value of the score.
The mutations were found at L112F and A240V in the NS4B protein at a frequency of 30%, while other mutations occurred at a frequency of 10%.
Unlike the other mutations occurred at residues in the conserved Greek-key motifs, the S228P mutation did not disrupt the hydrophobic core directly.
We did not find any other mutations, such as mutations at codons 10, 11, 15, 18, 19 or 22.
The other mutations were located at exon 5 of patient No. 9, exon 6 of patient No. 18, exon 10 of patient No.17, exon 11 of patient No. 1, exon 18 of patient No. 4 and No. 22, exon 20 of patient No. 20 and exon 22 of patient No. 8 and No.19.
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