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This pluripotent state is characterized by maintenance of transcriptionally permissive chromatin, which underlies high genome plasticity from which other gene expression patterns are derived during development [ 1- 4].
Changes associated with altered insulin signaling and other gene expression patterns could help explain the remarkable longevity of bowhead whales as well as their adaptation to a lipid-rich diet.
Because senescent cells remain metabolically active even through they can no longer divide, we were also interested in other gene expression patterns in senescent annulus cells, and in how these patterns differed from those in non-senescent cells.
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Other informative gene expression patterns may be missed when focusing on gene sets or molecular concepts.
Many other spatial gene expression patterns generated via RNA ISH such as FlyBase (Drysdale, 2008) and Mouse Atlas (Lein et al., 2006) provide rich information for genetics.
The expression pattern of ClCdx has been described previously [ 58, 61] but here we focus on a detailed description of the anterior expression associated with the acoel nervous system and its relationship to other Hox gene expression patterns.
Figure 1a shows that the observed patterns aggregate in rectangular "blocks" of high correlation, indicated in red, corresponding to samples that are highly similar to each other in gene expression patterns.
We believe that other probes with gene expression patterns in high correlation with the probes discussed in this paper, and perhaps less studied by immunohistochemistry and other methods in the two cancer types studied here, are worth exploring as a group of biomarkers.
As shown in Figure 2 and Additional file 1, the RT-qPCR and microarray analysis results correlated well with each other, with similar gene expression patterns seen for each of the ten individual genes during the different growth stages tested.
This proof-of-principle study establishes a theoretical basis to identify cancers in other organs by studying gene expression patterns or other molecular signatures in their matching normal epithelia.
In other words, the Hox gene expression patterns shown in previous studies could represent expression of one or both paralogs, whereas expression of the other has gone undetected or undifferentiated.
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