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It is reported that malignant or nonmalignant mammary epithelial cells, as well as other differentiated cell types, lose many aspects of differentiation upon dissociation and culture in 2D on TCP.
As seen in other differentiated cell types, several TAFs are down-regulated upon motor neuron differentiation.
Demethylation at the PDGFR-β promoter has been identified in previous screens comparing hES cell methylation profiles to other differentiated tissues [25], and may represent an important site of regulation during differentiation.
Gene expression monitoring at E15.5 and E17.5 showed no change in Osx but decreased Bril itself as well as other differentiated osteoblast markers (Ibsp, Bglap, Sost).
However, the presence of iron meteorites and achondritic meteorite classes without identified parent bodies indicates that there once were other differentiated planetesimals with igneous histories, which have since been shattered by impacts.
The nature of the other differentiated cells remains unclear although they are heterogeneous [22]; for the purpose of the present study we classified them as 'non-neuronal'.
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Alternatively, they might be derived from other abnormally differentiated cells, because the differentiation of basal cells to luminal cells also occurs at later stages than P14 (23).
Disruption of ICM signaling leads to trophoblast differentiation into giant cells or other terminally differentiated placental cell types [1], [3].
In the other, each differentiated product is produced by a single monopolist.
On the other hand, differentiated tissues derived from human or mouse iPSCs can readily tolerate temporary MYC inactivation.
Because of cloning's inherent inefficiencies, the nuclear transfer experiments using lymphocytes and other terminally differentiated cells as nuclear donors must be carefully designed and carried out.
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