It remains unknown whether this resistance has a unique origin with the same molecular basis or is multifactorial.
Nevertheless, trait variation largely followed phylogenetic boundaries as defined by haplotype structure and geographic origin: strains with the same haplotype or the same geographic origin were significantly (Student t-test, P < E−34) more similar than other strains.
When examining parent-of-origin effects with the same sample and a parent-of-origin risk factor of 2.5, the power was higher than 92%, and type I error rate was consistent with the nominal 0.05 (Weinberg et al. 1998).
For each of the eight tissues in analysis, we computed the list of Membranome genes up- and down-regulated in the primary tumors as compared to the corresponding cell line, with the same tumor tissue origin (Table S3).
In the 24 A-T adults with a tumour, 11 were of lymphoid origin, 7 with the same spectrum as the paediatric lymphoid tumours (Table 2).
More and more investigators suggest that cancers of different organs of origin, but with the same molecular targets, should be managed together because the common molecular targets observed in diverse tumors determine clinical practice better than organ-based classification [ 31].
Evidence here presented suggests a long-term effect of purifying selection probably predating modern human origins (200,000 years), with the same strong functional constrains acting across different primate species for at least 5 Myr.
Though the Earth-Two Batman is erased from history, many stories of Batman's Silver Age/Earth-One career (along with an amount of Golden Age ones) remain canonical in the post-Crisis universe, with his origins remaining the same in essence, despite alteration.
Interestingly, extensive sequence analysis in this and previous studies indicates that both the traditional and modern fragrant rice varieties with diverse origins possess the same mutant allele, suggesting the donor mutation leading to fragrance probably has a single evolutionary origin [ 22].
Animal experimental tumorigenesis occurs in which ovarian surface epithelium is the origin of tumours with the same molecular characteristics as high-grade serous cancers [ 83, 84].
