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Woodward, A. et al. Excess Mcm2 7 license dormant origins of replication that can be used under conditions of replicative stress.
The chromosomes replicate from multiple starting-points (origins of replication) using DNA polymerases that resemble the equivalent eukaryotic enzymes.
(A) A DNA fiber example with three origins of replication and the inter-origin distances (IOD) (see Methods).
Although inactive, these loaded double hexamers mark all potential origins of replication and are poised for bidirectional initiation.
Morgane Macheret and Thanos Halazonetis demonstrate that oncogene activation in human cancer cells results in firing of ectopic origins of replication within transcribed genes.
Replication initiates at multiple sites (called origins of replication) distributed across each chromosome.
The human sequences were shown to be responsible for the replication activity and may represent authentic human origins of replication.
Recently, the origins of replication in Hfx.
The process of DNA replication generally begins at specific sites known as origins of replication.
The majority of AAV serotypes possess highly conserved origins of replication with interchangeable DNA-protein interactions.
Localization of these elements may also facilitate the identification of other unique Parvovirus origins of replication.
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