As for replication origins, matrix-scaffold attachments regions (MARs) required for attachment of chromatin to the nuclear matrix are also found in intergenic regions (Glazko et al. 2003).
We obtained 100 HSAs using a patient origin matrix containing over four million discharges.
The patient origin matrix for NSRI confirmed the accuracy of the denominator/hospital catchment area from the patient flow analysis.
Finally we performed a denominator sensitivity analysis using a patient origin matrix based on Hospital Episodes Statistics (HES) to validate our approach.
First, we used the home ZIP codes of patients admitted with psychiatric disorders to create a patient origin matrix for all adult psychiatric admissions.
These results as well as the NSRI market area constructed from the HES/TARN patient origin matrix supports our approach as relatively robust.
Therapeutic options are presently limited to 2 neuraminidase (NA) inhibitors, oseltamivir and zanamivir, because this virus has a swine-origin matrix 2 (M2) gene, which contains a mutation associated with resistance to M2 ion channel blockers amantadine and rimantadine.
It is noteworthy that whereas patient flow concerns a proportion of each hospital's local patients (in this study defined by a minimum of 80%), the patient origin matrix allows delineation of the entire hospital market area.
Apart from NSRI area the patient origin matrix shows the catchment area for Staffordshire General Hospital (i.e. ST15 to ST21) with one competitor and main provider for the district ST14, which is Queen's Hospital.
The notion of market area (Hospital Service Area – defined by means of patient origin matrix) has been recently employed by researchers in Switzerland to describe utilization of health care services [ 24] whereas in the UK, Propper et al. have used market areas (defined by patient travel time) to look at the relationship between quality and competition in the UK health care system [ 27].
These triple reassortants contained polymerase acidic (PA) and polymerase basic 2 (PB2) genes of avian virus origin; hemagglutinin (HA), neuraminidase (NA), and polymerase basic 1 (PB1) genes of human virus origin; and matrix (M), nucleoprotein (NP) and nonstructural (NS) genes of classical swine virus origin (13 ).
