We report on a patient treated with the originator drugs such as epoetin theta, epoetin beta and darbepoetin alfa, who developed ESA-induced PRCA.
Pharmacometric approaches can assist in biosimilar development by leveraging quantitative knowledge of the originator product characteristics such as dose exposure and exposure response information to support a targeted approach to clinical studies.
This suggests that other factors could drive price differences between originators and their equivalents, such as regulatory skill and procurement ability.
Lending standards had indeed deteriorated, as mortgage originators introduced such "innovations" as no-money-down loans that required little or no financial information about the borrower — and loan applications that practically begged borrowers to fib about their income.
–Private label bonds are issued by financial institutions such as large mortgage originators or Wall Street firms.
This includes greater utilisation of originators versus generics as well as injectables when cheaper oral equivalents are available.
Gottfried Leibniz, Francis Bacon, and Bishop Berkeley appear next to more contemporary luminaries such as Norbert Wiener (the originator of cybernetics), Vladimir Zworykin (a pioneer of television) as well as numerous members of the Huxley family (Aldous, Julian and Thomas).
The draft bill would have given police and the security services access, without a warrant, to details of all online communication in the UK – such as the time, duration, originator and recipient, and the location of the device from which it was made.
In contradiction of the police claim that they needed more time to liaise with foreign jurisdictions, the head of MI5 is on record as saying that this country could not make inquiries of a regime such as Algeria (to discover if the originator of information had been tortured) lest it stop the free flow of information.
The vertical format can easily accommodate variables that link to other tables, describing additional data such as sampling location and methods, data originator, data provenance, and other metadata that may be needed for specific analyses.
