Exact(6)
While the role of Antarctica may never be fully understood as long as most of it is ice-covered, it is evident that the continent now at the South Pole played a major role, serving perhaps as originator as well as spreader of species.
The slimmer man dismissed Mr Santamaría's barbs as total nonsense, and their originator as a staid old conservative.
We'll leave the last word to the late, Bo Diddley, "The Originator" as he was called because of the key role his music played in the transition from blues to rock.
However, even the originator as a source is not a guarantee of authenticity.
While the developer of a biosimilar has access to the originator as a final product, there is no direct access to the proprietary development data.
Those studies with the EU-approved originator as a comparator demonstrated similarity across doses ranging from 1 10 µg/kg in both single-dose and multiple-dose settings for subcutaneous and intravenous administration.
Similar(54)
Bernard Weinraub, in "An Unusual Choice for the Role of Studio Superhero" [July 9], refers to Stan Lee as the creator of "The X-Men," totally ignoring Jack Kirby's status as the series' co-originator as well as the contributions of the many writers and artists who intermittently revamped the often reincarnated comic book series.
Both aspire to do more: to become "research-based" (Ranbaxy), "discovery-led" (Dr Reddy's) originators as well as cheap and clever copycats.This would be a remarkable turn-around for an industry hampered by a history of protection, price control and licensed piracy.
These include measures to engineer low prices for generics and originators as well as interchangeable brands within a class [ 2, 11- 16].
No doubt many useful datasets of this type exist in the databases of commercial organisations, but they need to become public as the likelihood is that crowdsourcing analyses would add value for their originators as well as for the common good.
Product classes include biosimilars and originator products as well as me-too pharmaceuticals (second-generation products are excluded).
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Justyna Jupowicz-Kozak
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