The modifier factors originating early-onset CRC in this 27-year-old patient remain unknown, but some data suggest that multiple mutations in different genes may influence the penetrance of the disease (Scheenstra et al, 2003; Soravia et al, 2005; Okkels et al, 2006).
These data also suggest that the PM3 proteins originated early in the life of the plant kingdom, predating the origin of flowering plants.
Authentic story originated early in century.
They originated early in the 19th century as an offshoot of the Nguni of Natal.
The first bobbin lace is not well documented, but it probably originated early in the 16th century.
Although this festival originated early in the East, probably at Jerusalem in 543, its first Western observance was recorded in England in the 11th century.
The Yorkshire pig, which originated early in the 19th century in England, where it was considered a bacon type, is long, lean, and trim with white hair and skin.
The attack appears to have originated early this morning, when a handful of blog posts popped up detailing the worm.
Airway SM originates early in the developing lung mesenchyme, during formation of the bronchial tree, through a mechanism that is distinct from that of the lung vascular musculature.
As with essentialism, this intuitive inclination toward purpose-based teleological explanations appears to originate early in childhood and, unless it is challenged, persist into adulthood (Evans 2000a, 2001, 2008; Poling and Evans 2004; Kelemen 1999a, b, c, Kelemen 2011).
