The concept of Lightning Returns originated during development of XIII-2, while the development team was brainstorming ideas for possible continuations of the story and universe of the games, though there was no solid decision to make a second sequel to XIII at the time.
This paper first outlines some of the motivations that originated the development of AMUSE.
To determine whether the differences in PV expression originated during development or were confined to adulthood, we next examined PV expression in animals at postnatal day (P 14, the period during which PV expression rapidly increases in the rodent brain.
Mild retinal dysplasia was observed in the Rb+/-; p107-/ mice at 4 to 6 months of age, and histologic analysis of postnatal day (P) 4 retinas suggested that dysplasia originated during development [ 13].
Like Somel et al. (19), Lui et al. (21) found that many age-dependent gene expression changes, including those in cell-cycle-related genes, originate in development and in particular during the period of juvenile growth deceleration.
It originates in development economics, and it refers to a country's ability to use external assistance effectively.
Here, I review these recent findings and put forward a model of how programmatic features originating in development may contribute to aging.
The combination of these defects suggests that they might originate during development from a misbalance between neural and non-neural ectoderm in the early embryo.
Some of the gene expression and epigenetic changes originating in development may well turn out to be detrimental during aging or reflect developmentally triggered changes, for instance, in cell proliferation or differentiation, that alter gene expression patterns.
Synthesis of paleontological and developmental data indicates that the genetic program for fin development originated in median fins, and the evolution of paired fins involved re-deployment of this genetic circuit to the lateral plate mesoderm [7].
Surprisingly, despite an extensive effort, I could find no explanation in the literature for why or how development originated and no proposal for a benefit provided by multicellularity-plus-development versus multicellularity.
