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The presence of this gene family in placental mammals, marsupials and monotremes but not in reptiles/birds or other vertebrate species, indicates that this family originated at the onset of mammal evolution, before divergence of Theria and Prototheria.
However, among mammals we identified orthologs of CCT8L genes in genomes not only of placental mammals (Eutheria), but also of the marsupial opossum (Metatheria) and of the egg-laying platypus (Prototheria), suggesting that the CCT8L gene class originated at the onset of mammal evolution.
In these analyses, not all genes in one comparison have originated at the same time, but biases due to orthologous group specific evolution rates are absent.
(It originated at the Donmar Warehouse, in London).
The flight originated at the Naval Air Engineering Center at Lakehurst, N.J.
The concept actually originated at the dawn of the automobile.
Few people realize they originated at the bake-off.
Lloyd's "Julius Caesar," which originated at the Donmar Warehouse in London.
Note that many of the posts to this blog originated at "The Evolution List".
The tumor originated at the trabecular muscle.
The state originated refers to the case that the frame is originated at the node in concern.
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