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Originally identified for its role in neurogenesis, DCLK1 has recently been shown to regulate biological processes outside of the CNS.
WWF-UK's head of marine policy Dr Lyndsey Dodds said the 14 sites had been dropped from the 37 originally identified for this round of consultation despite clear cross-party and public support.
CRTL1 (also known as link protein) is a small glycoprotein of the extracellular matrix that was originally identified for its role in stabilizing aggregates of aggrecan and hyaluronan in cartilage.
Of note, Clock∆19 strain, the CLOCK truncated line that was originally identified for its significant period change from a random mutagenesis screen, is with milder aging phenotypes such as diurnal activity/feeding rhythms and obesity in normal housing conditions compared to the knockout strain (Turek et al., 2005).
OGC was originally identified for its ability to transfer α-ketoglutarate across the inner mitochondrial membrane.
Bone morphogenetic proteins (BMPs), originally identified for their ability to induce bone differentiation, are members of the TGF-β superfamily.
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Hsc70 homologs appear to function as 'disassemblases' in other contexts for example, in taking apart an origin recognition complex in DNA replication, the originally identified role for DnaK and DnaJ in bacteriophage λ replication (Alfano and McMacken, 1989).
Therefore, we constructed a capsule-deficient strain of C. gattii, using a homolog of the C. neoformans CAP59 gene, for directed disruption, because this gene was originally identified as critical for capsule synthesis [14].
NAIP was originally identified while searching for a gene on chromosome 5q13 responsible for childhood muscular atrophy and is also associated with spinal muscular dystrophy [ 23, 24].
Such inhibitors were originally identified while searching for compounds that could prevent the activation of procaspase-9 when analyzed in an in vitro reconstituted apoptosome (Malet et al., 2006).
Mutations in rpm-1 were originally identified in screens for mutants with aberrant NMJ presynaptic boutons [5], [6].
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