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In the 1960s MVA was originally generated as a candidate virus for safer vaccination against smallpox.
TLR4−/−, MyD88−/− and TRIF-mutant mice were originally generated as described previously [37], [38], [39], and the correct phenotype was revealed by genotypic screening.
Alternatively, CRoPS is based on sequencing DNA fragments that were originally generated as AFLP markers.
This is best exemplified by mAb 57B, which was originally generated as a MAGE-A3 reagent [ 20].
PS1-KI mice used in the study harbor the FAD-linked mutation of presenilin 1, PS1M146V, and were originally generated as a hybrid 129/C57BL6 background.
I-BET151 is a synthetic compound, originally generated as a reagent to target the epigenetic codes of the genome (Nicodeme et al., 2010).
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Transgenic flies were generated as above.
In a similar fashion, the large, spherical QDs appear to regress back to their origins as many smaller, irregularly shaped QDs originally generated within the as-oxidized Si1-xGe x layers.
Plasmid encoding the hyperactive T. ni piggyBac transposase, as originally generated by Nancy Craig et al. (Li et al., 2013), was obtained from System Biosciences.
We used a library originally generated for an Hfq Genomic SELEX experiment, generated as described in the protocol [3].
Photochemically active hematoporphyrin derivatives (HPDs), including hematoporphyrin, photofrin II, ATX-70, and ATXS10, have been demonstrated to induce cell death when activated by ultrasound irradiation, indicating that these chemicals, which were originally generated for PDT, are applicable as sonosensitizers [ 9].
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