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Long-chain polyunsaturated fatty acids (LC-PUFAs) can be produced de novo via polyketide synthase-like enzymes known as PUFA synthases, which are encoded by pfa biosynthetic gene clusters originally discovered from marine microorganisms.
Over the past decade, our group has developed several series of dimeric acetylcholinesterase (AChE) inhibitors derived from tacrine and huperzine A, a unique anti-Alzheimer's drug originally discovered from a traditional Chinese medicinal plant.
LASP-1 is a cytoskeletal scaffold protein originally discovered from the cDNA library of human metastatic breast cancer [20].
Most genetic components of the clock were originally discovered from a light-entrained oscillator.
The Tol2 transposon was originally discovered from Medaka fish (Orzyias latipes) [ 12].
Enterokinase was originally discovered from the succus entericus of the dog (Schepowalnikow, 1899; Pavlov, 1910).
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Although restriction enzymes were originally discovered for their ability to attack invading DNAs, it may be understood because such DNAs show deviation from this epigenetic status.
This PTM activity was originally discovered in toxins from bacterial intracellular pathogens5 and later identified in the toxin component of bacterial toxin/antitoxin (TA) modules (e.g., Bartonella VbhT/VbhA8) and in various other bacterial FIC proteins of unknown functions, including single-domain (e.g., Neisseria FIC8) and larger (e.g., Clostridium FIC12) FIC proteins.
Fifteen MITEs were originally discovered as insertions from interrupted pseudogenes.
The first zinc-containing thermostable metallopeptidase was originally discovered and purified from Thermus aquaticus and had an optimal enzymatic activity at 80°C [ 85].
Xenotropic murine leukemia virus related gammaretrovirus (XMRV) was originally discovered in tissue from patients with familial prostate cancer homozygous for a missense mutation in the RNase L gene, R462Q (1 ).
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