Sentence examples for originally been characterized from inspiring English sources

Ubiquitin has originally been characterized as a covalently attached signal for ATP-dependent proteasomal degradation of substrate proteins (Hershko and Ciechanover, 1998), although it also plays a role in both the lysosomal and autophagic degradation pathways (Clague and Urbe, 2010).

The biochemical cascade that executes autophagy has originally been characterized at a molecular level in yeast (Saccharomyces cerevisiae) [ 7, 8].

Cardiac ATDPCs had originally been characterized as MSC-like cell progenitors, with over 90% of cells staining strongly positive for CD105, CD44, CD166, CD29, and CD90 and negative for CD106, CD45, and CD14 [ 8].

Bacterial toxin-antitoxin systems (TAS, also referred to as TA loci) originally have been characterized in the 1980s as molecular systems encoded in plasmids and ensuring the persistence of a plasmid in a host lineage during replication by making the cells "addicted" to the plasmid so that only plasmid-containing daughter bacteria survived after a cell division [ 1, 2].

Originally, sialoadhesin was characterized as a lymphocyte adhesion molecule, though recently its involvement in internalization of sialic acid carrying pathogens was shown, suggesting that sialoadhesin is an endocytic receptor.

Originally, HDAC4 was characterized as a histone deacetylase regulating transcription factors MEF2 [ 20] and Runx2 [ 25].

Originally, these compounds are characterized by their ability to interact with integrins αIIb β3, α5 β1, and αv β3lls expressed by a number of cells including those involved in tumor development and proliferation [ 150, 151].

Third, T. formosanum, originally described from Taiwan, was characterized by black ascocarp with apex warts and spores with free straight spine or irregular reticulum, which discriminated it them from other species (Figure 1g, h).

LEC was characterized originally from an O. flavescens mouse trapped in the Rio de la Plata River, an area where several HPS cases had occurred (6 ).

S. thermophilum is a thermophilic bacterium originally isolated from compost and is characterized by a marked growth dependence on microbial commensalism.

As originally described [ 24], PRIS was characterized by rhabdomyolysis, hyperkalemia, metabolic acidosis, and renal and cardiac failure and is associated with a high mortality.