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These values were normally distributed, so the original values were used for analyses.
Original values were used for reaction rate constants, but initial concentrations of some variables have been adjusted to the physiology of cardiac myocytes (see Table 4 for details).
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Pearson's correlation coefficient, which is based on the original values, was used for the total scores in order to assess the linear association of the more continuous total scores.
FM dye intensity (Δ F/ F where F is the original value) was used to quantify the kinetics of cell membrane repair and represented with intervals of five frames.
The following relationship between glucose and HbA1c was derived in the original publication and applied here for prediction: The original parameter values were used for method comparison.
We did not modify the model itself, and confirmed that our implementation accurately reproduced the results [ 1] when the original constant values were used.
T3 was not normally distributed (p < 0.001 using a one sample Kolmogorov Smirnov test), but to give estimates more readily interpretable, the original T3 values were used to obtain HRs.
Original, non-seasonally adjusted values were used, to be consistent with the ED time series.
In order to compare variables effects between models, original variables without lagged values were used for ridge regression analysis directly.
For cluster analysis of the tissue expression profiles of the various ZNF genes the original relative quantitative RT-PCR values were used to calculate trees: The ZNF gene tree is based on Pearson correlation distances and the tissue tree on euclidean distances, both with single linkage, using R software http://www.r-project.org.org
The mean, median, minimum and maximum values are reported on original data; t-tests of log-transformed values were used to test differences in quantitative variables.
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