Exact(5)
Mr Bhidé argues that this downstream innovation, which is far more complex and customised than the original upstream invention, is the most valuable kind and what America is best at.
However, later transcription inhibits the original upstream signal by negative feedback once the signal becomes unnecessary.
This type of pathway architecture can lead to significant amplification of the original upstream receptor/ligand binding signal.
A motif identified in the original upstream set was regarded as significant: (i) if it was not identified in the shuffled sets and (ii) if its scores were better than the scores obtained for the random motifs.
The modified pUC19 vector was constructed by generating NcoI and NotI sites at the terminal ends of the pUC19 wild-type TEM-1 gene sequence by site directed mutagenesis (QuickChange Mutagenesis) to allow the wild-type TEM-1 gene to be deleted (leaving the original upstream regulating sequences intact).
Similar(54)
Thus, over-represented motifs identified by MEME in the original sets of upstream sequences were significant because they were not picked in any of the randomized sequences.
To decrease YhjH expression, we designed a series of ribosome-binding sites (RBS) with predicted lower translation initiation efficiencies and used them to replace the original RBS (RBS1) upstream of yhjH.
The Ensembl database shows that Sumatran orangutan still has at least part of that original Wdnm1-like gene upstream of HEATR6, but information of that region is incomplete.
The original MEE2 motif identified upstream of the upsC var gene PFL1960w is shown as the first sequence in the alignment.
The motifs identified in the shuffled sets (if any), and their scores (e.g., MAP score for AlignACE motifs), were compared with the motifs and scores obtained with the original, unshuffled set of upstream sequences.
The difference to the original T7 gene 10 upstream sequence [ 26] is a deletion of an 8 bp sequence between the stem-loop and SD which was replaced by the recognition site of restriction endonuclease AflII.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com