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Its original significance was as a guardian presence in a Buddhist temple.
Here the distinction between vaults and domes has lost its original significance, being based only on the type of curvature in the slab.
Etymologically the word marquess or margrave denoted a count or earl holding a march, or mark, that is, a frontier district; but this original significance has long been lost.
Leo Frobenius, the originator of the theory that later became known as the Kulturkreislehre, distinguished the creative or expressive phase of a culture, in which a new insight assumes its specific form, and the phase of application, in which the original significance of the new insight degenerates.
At first the image of Che was worn as a statement of rebellion, then as the epitome of radical chic, and, with the passage of time, as a kind of abstract logo whose original significance may even have been lost on its wearer, though for some he remains an enduring inspiration for revolutionary action.
When scientific topics are reported, they are consistently misunderstood and spiced-up with such sensationalism that the original significance is contorted beyond all recognition.
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At a recapitulatory final meeting ("team review" in Figure 1) the team appraised the translated questionnaire according to four criteria: adherence to the original meaning, significance for TCM, clinical usefulness, and psychological impact on patients.
Across all 301 tested C2 gene sets, the improvement in the enrichment FDR after EMVC optimization was positively correlated with the original enrichment significance of the gene set, i.e. gene sets with significant enrichment values using the unoptimized annotations were most likely to benefit from optimization.
By the time these stories reached the form we know today, they had long lost their original ritual significance, which probably goes back to the very remote period when matriarchal societies were giving way to male-dominated cultures, with Medea's repeated expulsions or flights reflecting the suppression of Earth-goddess cults.
There were, however, 2 variables that lost their original statistical significance: treatment with antidepressants and recent use of illicit drugs.
Only under the dominant model was there a modest improvement over the original statistical significance for the two SNPs rs4845618 and rs4845374.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com