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Interestingly, a composite origin profile around the center of either H3K4me3 (599 sites) or Pol-II (138 sites) binding sites revealed a strong correlation (Fig. 4C).
Using a window of 500 bp to define the positioning of peak signals, a composite origin profile at the 5'-end of all genes present in the array was generated.
By explicitly modeling the cancer cell expression profile as a perturbation of the site of origin profile, our model is a more precise representation of cancer that naturally leads to the identification of differentially expressed genes as those whose expression was perturbed to produce the tumor expression profile.
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After all, revisions to racial profiling rules that retain loopholes permitting racial, religious and national origin profiling are not the reforms that Americans need and deserve.
It would also be of considerable interest to compare origin profiles between isogenic normal and cancer cells to determine if origin selection is altered in transformed cells.
Additional file 2 summarized the origin profiles of total small RNAs.
Another recent report on king cobra(s) venom of probable Thai origin profiled the venom as well, detecting 14 protein types/families (including hypothetical proteins), but again without the estimation of relative toxin abundance [ 25].
Understanding of CSC's origin, molecular profile, and interaction with their microenvironments, this could be a paradigm shift in the treatment of cancer, away from targeting the blast cells and towards the targeting of the CSC, thus improving therapeutic outcome.
No difference in underlying disease, primary versus secondary origin, biochemistry profile, or average length of hospital stay was found between the 2 groups.
RNA extracted from MVs and cells of origin was profiled for 365 known human mature miRNAs by real time PCR.
However, we could not identify a reproducible parent-of-origin methylation profile for these CpGs, suggesting that other genomic regions in CADPS2 or other regulatory mechanisms may be related to the presence of a monoallelic pattern of expression.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com